Recombinant PD-1 antibody

Catalog No. ABIN7795529

This Mouse Bispecific antibody specifically detects PD-1 in FACS, WB, IHC, ELISA, ICC and in vivo. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant PD-1 antibody (ABIN7795529)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Mouse

Clonality: Bispecific

Conjugate: This PD-1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), In vivo Studies (in vivo)

Grade: In vivo Grade

Clone: 29F-1A12-1-RMP1-14-1

Product Details anti-PD-1 Antibody

Expression System: Mammalian cells

Purpose: In Vivo Grade Recombinant Anti-mouse PD-1 / PD-1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 29F.1A12.1 / RMP1-14.1)

Characteristics: Are you looking for a better anti-mouse PD-1 monoclonal antibody than the clones of RMP1-14 and 29F.1A12. The rat anti-mouse PD-1 monoclonal antibodies (clone No. RMP1-14, rat IgG2a kappa, and clone No. 29F.1A12, rat IgG2a kappa) bind to different epitopes of the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. Both RMP1-14 and 29F.1A12 antibodies block the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein. It is under investigation whether either of the recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (RMP1-14 / 29F.1A12 and 29F.1A12 / RMP1-14) is the best anti-mouse PD1 antibody. Our recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (combination of RMP1-14 and 29F.1A12) have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14 and 29F.1A12).

Purification: Protein A or G affinity column

Purity: >95 % by reducing SDS-PAGE

Endotoxin Level: < 1 EU per 1 mg of the protein by the LAL method

Isotype: IgG2c, L234A, L235A, P329G, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: > 3 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: PD-1 & PD-1

Sub Type: Bispecific

Pathways: Cancer Immune Checkpoints